ProtASR2: Ancestral reconstruction of protein sequences accounting for folding stability

We developed a new version of our program “ProtASR” to infer ancestral sequences of proteins accounting for the protein folding stability. A methodology that produces more realistic ancestral sequences respect to those obtained using traditional empirical substitution models. This study was done in collaboration with Ugo Bastolla (Center for Molecular Biology Severo Ochoa). Just published in Methods in Ecology and Evolution, https://besjournals.onlinelibrary.wiley.com/doi/abs/10.1111/2041-210X.13341

The Early Peopling of the Philippines based on mtDNA

We investigated the peopling of the Philippines by modern humans, including the estimation of evolutionary parameters and migration patterns such as migration corridors connecting the continent with the archipelago and the presence of long-distance dispersal. This study was done in collaboration with the lab of Antonio González-Martín (University Complutense of Madrid). Just published in Scientific Reports,

https://www.nature.com/articles/s41598-020-61793-7

Investigated migration corridors towards the Philippines.

Consequences of diverse evolutionary processes on american genetic gradients of modern humans

The genetic gradient of modern humans of the Americas present a northwest-southeast direction along the entire continent. However at regional levels the genetic gradient can present directions directions as a consequence of population and environmental processes. Just published in Heredity,

https://www.nature.com/articles/s41437-018-0122-x