ProtASR2: Ancestral reconstruction of protein sequences accounting for folding stability

We developed a new version of our program “ProtASR” to infer ancestral sequences of proteins accounting for the protein folding stability. A methodology that produces more realistic ancestral sequences respect to those obtained using traditional empirical substitution models. This study was done in collaboration with Ugo Bastolla (Center for Molecular Biology Severo Ochoa). Just published in Methods in Ecology and Evolution,

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